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A functional role for the ventrolateral prefrontal cortex in non-spatial auditory cognition.


ABSTRACT: Spatial and non-spatial sensory information is hypothesized to be evaluated in parallel pathways. In this study, we tested the spatial and non-spatial sensitivity of auditory neurons in the ventrolateral prefrontal cortex (vPFC), a cortical area in the non-spatial pathway. Activity was tested while non-human primates reported changes in an auditory stimulus' spatial or non-spatial features. We found that vPFC neurons were reliably modulated during a non-spatial auditory task but were not modulated during a spatial auditory task. The degree of modulation during the non-spatial task correlated positively with the monkeys' behavioral performance. These results are consistent with the hypotheses that the vPFC is part of a circuit involved in non-spatial auditory processing and that the vPFC plays a functional role in non-spatial auditory cognition.

SUBMITTER: Cohen YE 

PROVIDER: S-EPMC2785289 | biostudies-other | 2009 Nov

REPOSITORIES: biostudies-other

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A functional role for the ventrolateral prefrontal cortex in non-spatial auditory cognition.

Cohen Y E YE   Russ B E BE   Davis S J SJ   Baker A E AE   Ackelson A L AL   Nitecki R R  

Proceedings of the National Academy of Sciences of the United States of America 20091106 47


Spatial and non-spatial sensory information is hypothesized to be evaluated in parallel pathways. In this study, we tested the spatial and non-spatial sensitivity of auditory neurons in the ventrolateral prefrontal cortex (vPFC), a cortical area in the non-spatial pathway. Activity was tested while non-human primates reported changes in an auditory stimulus' spatial or non-spatial features. We found that vPFC neurons were reliably modulated during a non-spatial auditory task but were not modulat  ...[more]

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