Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC2786808 | biostudies-other | 2009 Dec
REPOSITORIES: biostudies-other
Huang Jian J Zhang Yi Y Bersenev Alexey A O'Brien W Timothy WT Tong Wei W Emerson Stephen G SG Klein Peter S PS
The Journal of clinical investigation 20091201 12
Hematopoietic stem cell (HSC) homeostasis depends on the balance between self renewal and lineage commitment, but what regulates this decision is not well understood. Using loss-of-function approaches in mice, we found that glycogen synthase kinase-3 (Gsk3) plays a pivotal role in controlling the decision between self renewal and differentiation of HSCs. Disruption of Gsk3 in BM transiently expanded phenotypic HSCs in a betta-catenin-dependent manner, consistent with a role for Wnt signaling in ...[more]