Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC2786840 | biostudies-other | 2009 Dec
REPOSITORIES: biostudies-other
Li Zhihua Z Kim Sang Woo SW Lin Yuefeng Y Moore Patrick S PS Chang Yuan Y John Bino B
Journal of virology 20091007 24
Recently identified small (20 to 40 bases) RNAs, such as microRNAs (miRNAs) and endogenous small interfering RNAs (siRNAs) participate in important cellular pathways. In this report, we systematically characterized several novel features of human and viral RNA products smaller than miRNAs. We found that Kaposi sarcoma-associated herpesvirus K12-1 miRNA (23 bases) associates with a distinct, unusually small (17-base) RNA (usRNA) that can effectively downregulate a K12-1 miRNA target, human RAD21, ...[more]