New agents for AML and MDS.
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ABSTRACT:
SUBMITTER: Grant S
PROVIDER: S-EPMC2793080 | biostudies-other | 2009 Dec
REPOSITORIES: biostudies-other
Publications
New agents for AML and MDS.
Best practice & research. Clinical haematology 20091201 4
The heterogeneity of acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS) has led to a multiplicity of treatments, from cytotoxic agents to signal transduction modulators, cell-cycle inhibitors and epigenetic therapies. While some have shown promising initial results, the outlook for AML patients, particularly older and relapsed patients, as well as patients whose cells exhibit certain adverse chromosomal abnormalities or mutant oncoproteins, continues to be grim. Combination chemot ...[more]
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