InGAP: an integrated next-generation genome analysis pipeline.
Ontology highlight
ABSTRACT:
SUBMITTER: Qi J
PROVIDER: S-EPMC2796817 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Publications
inGAP: an integrated next-generation genome analysis pipeline.
Qi Ji J Zhao Fangqing F Buboltz Anne A Schuster Stephan C SC
Bioinformatics (Oxford, England) 20091030 1
<h4>Summary</h4>We develop a novel mining pipeline, Integrative Next-generation Genome Analysis Pipeline (inGAP), guided by a Bayesian principle to detect single nucleotide polymorphisms (SNPs), insertion/deletions (indels) by comparing high-throughput pyrosequencing reads with a reference genome of related organisms. inGAP can be applied to the mapping of both Roche/454 and Illumina reads with no restriction of read length. Experiments on simulated and experimental data show that this pipeline ...[more]
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