Ontology highlight
ABSTRACT:
SUBMITTER: Guibal FC
PROVIDER: S-EPMC2798860 | biostudies-other | 2009 Dec
REPOSITORIES: biostudies-other
Guibal Florence C FC Alberich-Jorda Meritxell M Hirai Hideyo H Ebralidze Alexander A Levantini Elena E Di Ruscio Annalisa A Zhang Pu P Santana-Lemos Barbara A BA Neuberg Donna D Wagers Amy J AJ Rego Eduardo M EM Tenen Daniel G DG
Blood 20091001 27
Acute promyelocytic leukemia (APL) is characterized by a block in differentiation and accumulation of promyelocytes in the bone marrow and blood. The majority of APL patients harbor the t(15:17) translocation leading to expression of the fusion protein promyelocytic-retinoic acid receptor alpha. Treatment with retinoic acid leads to degradation of promyelocytic-retinoic acid receptor alpha protein and disappearance of leukemic cells; however, 30% of APL patients relapse after treatment. One pote ...[more]