Ontology highlight
ABSTRACT:
SUBMITTER: Xia J
PROVIDER: S-EPMC2804799 | biostudies-other | 2009 Jun
REPOSITORIES: biostudies-other
Biology of reproduction 20090211 6
During mammalian fertilization, the contact between sperm and egg triggers increases in intracellular Ca(2+) concentration ([Ca(2+)](i)) in sperm. Voltage-gated Ca(2+) channels (Ca(V)s) are believed to mediate the initial phase of [Ca(2+)](i) increases in sperm induced by egg coat (zona pellucida [ZP]) glycoproteins, while store depletion-activated Ca(2+) entry is thought to mediate the sustained phase. Using patch-clamp recording and Ca(2+) imaging, we show herein that Ca(V) channel currents, w ...[more]