Ontology highlight
ABSTRACT:
SUBMITTER: Chalmin F
PROVIDER: S-EPMC2810085 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Chalmin Fanny F Ladoire Sylvain S Mignot Grégoire G Vincent Julie J Bruchard Mélanie M Remy-Martin Jean-Paul JP Boireau Wilfrid W Rouleau Alain A Simon Benoit B Lanneau David D De Thonel Aurélie A Multhoff Gabriele G Hamman Arlette A Martin François F Chauffert Bruno B Solary Eric E Zitvogel Laurence L Garrido Carmen C Ryffel Bernhard B Borg Christophe C Apetoh Lionel L Rébé Cédric C Ghiringhelli François F
The Journal of clinical investigation 20100119 2
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in tumor-bearing mice and humans and have been shown to contribute to cancer development. Here, we have isolated tumor-derived exosomes (TDEs) from mouse cell lines and shown that an interaction between TDE-associated Hsp72 and MDSCs determines the suppressive activity of the MDSCs via activation of Stat3. In ad ...[more]