Ontology highlight
ABSTRACT:
SUBMITTER: Webb TJ
PROVIDER: S-EPMC2810536 | biostudies-other | 2009 Jul
REPOSITORIES: biostudies-other
Webb Tonya J TJ Bieler Joan G JG Schneck Jonathan P JP Oelke Mathias M
Journal of immunological methods 20090514 1-2
Natural killer T (NKT) cells play a pivotal role in maintaining immune homostasis. They recognize lipid antigen in the context of CD1d molecules and subsequently produce cytokines that activate cells of both the innate and adaptive immune responses. Many studies examining patients with autoimmune disease or cancer have shown that there is a reduction in both NKT cell number and function. Due to the complexities of manipulating NKT cells in vivo, ex vivo expanded effector NKT cells would be an ex ...[more]