Ontology highlight
ABSTRACT:
SUBMITTER: Rezvani HR
PROVIDER: S-EPMC2817476 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Rezvani Hamid Reza HR Mahfouf Walid W Ali Nsrein N Chemin Cecile C Ged Cecile C Kim Arianna L AL de Verneuil Hubert H Taïeb Alain A Bickers David R DR Mazurier Frédéric F
Nucleic acids research 20091124 3
The regulation of DNA repair enzymes is crucial for cancer prevention, initiation, and therapy. We have studied the effect of ultraviolet B (UVB) radiation on the expression of the two nucleotide excision repair factors (XPC and XPD) in human keratinocytes. We show that hypoxia-inducible factor-1alpha (HIF-1alpha) is involved in the regulation of XPC and XPD. Early UVB-induced downregulation of HIF-1alpha increased XPC mRNA expression due to competition between HIF-1alpha and Sp1 for their overl ...[more]