Ontology highlight
ABSTRACT:
SUBMITTER: Park JH
PROVIDER: S-EPMC2824295 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Park Ji-Ho JH von Maltzahn Geoffrey G Xu Mary Jue MJ Fogal Valentina V Kotamraju Venkata Ramana VR Ruoslahti Erkki E Bhatia Sangeeta N SN Sailor Michael J MJ
Proceedings of the National Academy of Sciences of the United States of America 20091228 3
A significant barrier to the clinical translation of systemically administered therapeutic nanoparticles is their tendency to be removed from circulation by the mononuclear phagocyte system. The addition of a targeting ligand that selectively interacts with cancer cells can improve the therapeutic efficacy of nanomaterials, although these systems have met with only limited success. Here, we present a cooperative nanosystem consisting of two discrete nanomaterials. The first component is gold nan ...[more]