Ontology highlight
ABSTRACT:
SUBMITTER: Mengle-Gaw L
PROVIDER: S-EPMC282689 | biostudies-other | 1988 Dec
REPOSITORIES: biostudies-other
Mengle-Gaw L L Albertson D G DG Sherrington P D PD Rabbitts T H TH
Proceedings of the National Academy of Sciences of the United States of America 19881201 23
Cytogenetic abnormalities involving chromosome 14 band q32 are consistently observed in human T-cell tumors. Patients with ataxia-telangiectasia (AT) are especially prone to development of these tumors, which frequently carry either inversion inv(14)(q11;q32) or translocation t(14;14) (q11;q32) chromosomes. We have previously shown that the cytogenetic breakpoints of one t(14;14)(q11;q32) chromosome and two inv(14)(q11;q32) chromosomes in T-cell tumors from AT and non-AT patients join the T-cell ...[more]