Identification, cloning, and characterization of an immune activation gene.
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ABSTRACT:
SUBMITTER: Lipes MA
PROVIDER: S-EPMC282843 | biostudies-other | 1988 Dec
REPOSITORIES: biostudies-other
Publications
Identification, cloning, and characterization of an immune activation gene.
Lipes M A MA Napolitano M M Jeang K T KT Chang N T NT Leonard W J WJ
Proceedings of the National Academy of Sciences of the United States of America 19881201 24
We have identified an immune activation gene, denoted Act-2, by differential hybridization screening of an activated T-cell library. The gene is induced rapidly after T-cell activation with phytohemagglutinin, B-cell activation with Staphylococcus aureus Cowan I, and monocyte activation with lipopolysaccharide. We have isolated a cDNA containing the full-length coding region. The deduced amino acid sequence predicts an open reading frame of 92 amino acids, including a very hydrophobic N terminus ...[more]
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