Ontology highlight
ABSTRACT:
SUBMITTER: Pande K
PROVIDER: S-EPMC2835082 | biostudies-other | 2009 Mar
REPOSITORIES: biostudies-other
Pande Kalyan K Ueda Roanna R Machemer Todd T Sathe Manjiri M Tsai Van V Brin Elena E Delano Matthew J MJ Van Rooijen Nico N McClanahan Terrill K TK Talmadge James E JE Moldawer Lyle L LL Phillips Joseph H JH LaFace Drake M DM
Molecular therapy : the journal of the American Society of Gene Therapy 20090106 3
Intravascular delivery (1.5 x 10(9) particles and higher) of recombinant adenovirus (rAd) induces myeloid cell mediated, self-limiting hemodynamic responses in normal mice. However, we observed anaphylactoid-type reactions and exacerbated hemodynamic events following rAd injection in mice bearing malignant 4T1 mammary carcinoma. Because 4T1 tumors induce significant CD11b(+)Gr-1(+) myeloid cell expansion and activation, we set to determine whether this causes rAd-induced exaggerated responses. W ...[more]