Ontology highlight
ABSTRACT:
SUBMITTER: Duque S
PROVIDER: S-EPMC2835208 | biostudies-other | 2009 Jul
REPOSITORIES: biostudies-other
Duque Sandra S Joussemet Béatrice B Riviere Christel C Marais Thibaut T Dubreil Laurence L Douar Anne-Marie AM Fyfe John J Moullier Philippe P Colle Marie-Anne MA Barkats Martine M
Molecular therapy : the journal of the American Society of Gene Therapy 20090414 7
Therapeutic gene delivery to the whole spinal cord is a major challenge for the treatment of motor neuron (MN) diseases. Systemic administration of viral gene vectors would provide an optimal means for the long-term delivery of therapeutic molecules from blood to the spinal cord but this approach is hindered by the presence of the blood-brain barrier (BBB). Here, we describe the first successful study of MN transduction in adult animals following intravenous (i.v.) delivery of self-complementary ...[more]