Identification of a feline immunodeficiency virus gene which is essential for cell-free virus infectivity.
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ABSTRACT:
SUBMITTER: Tomonaga K
PROVIDER: S-EPMC283668 | biostudies-other | 1992 Oct
REPOSITORIES: biostudies-other
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Identification of a feline immunodeficiency virus gene which is essential for cell-free virus infectivity.
Tomonaga K K Norimine J J Shin Y S YS Fukasawa M M Miyazawa T T Adachi A A Toyosaki T T Kawaguchi Y Y Kai C C Mikami T T
Journal of virology 19921001 10
Feline immunodeficiency virus (FIV) contains at least three small open reading frames (ORFs) in the genome, in addition to the three structural genes. Two of these ORFs (putative vif and ORF-A) have unknown functions. Northern (RNA) blot analysis of mRNAs from an FIV-infected cell line showed that the putative-vif-specific mRNA was expressed as a 5.2-kb species. To examine the function of the putative vif gene, we constructed mutants carrying a deletion in either the vif-like gene or the rev gen ...[more]
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