How are nucleosomes disrupted during transcription elongation?
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ABSTRACT: Chromatin structure is a powerful tool to regulate eukaryotic transcription. Moreover, nucleosomes are constantly remodeled, disassembled, and reassembled in the body of transcribed genes. Here we propose a general model that explains, in quantitative terms, how transcription elongation affects nucleosome structure at a distance as a result of the positive torque the polymerases create as they translocate along DNA templates.
SUBMITTER: Zlatanova J
PROVIDER: S-EPMC2839809 | biostudies-other | 2009 Dec
REPOSITORIES: biostudies-other
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