Ontology highlight
ABSTRACT:
SUBMITTER: Rai D
PROVIDER: S-EPMC2840369 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Rai Deepak D Kim Sang-Woo SW McKeller Morgan R MR Dahia Patricia L M PL Aguiar Ricardo C T RC
Proceedings of the National Academy of Sciences of the United States of America 20100201 7
The mechanisms by which microRNA dysfunction contributes to the pathogenesis of diffuse large B cell lymphoma (DLBCL) are not well established. The identification of the genes and pathways directly targeted by these small regulatory RNAs is a critical step to advance this field. Using unbiased genome-wide approaches in DLBCL, we discovered that the oncogenic microRNA-155 (miR-155) directly targets the bone morphogenetic protein (BMP)-responsive transcriptional factor SMAD5. Surprisingly, we foun ...[more]