Ontology highlight
ABSTRACT:
SUBMITTER: Fathman JW
PROVIDER: S-EPMC2840445 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Fathman John W JW Gurish Michael F MF Hemmers Saskia S Bonham Kevin K Friend Daniel S DS Grusby Michael J MJ Glimcher Laurie H LH Mowen Kerri A KA
Proceedings of the National Academy of Sciences of the United States of America 20100204 8
Nuclear factor of activated T cell (NFAT) transcription factors are key regulators of gene transcription within immune cells. The NFAT-interacting protein, (NIP45), augments NFAT-driven IL-4 expression by a mechanism that relies on arginine methylation. To establish the function of NIP45 in vivo, we generated mice with a targeted deletion of the gene encoding this cofactor. NIP45-deficient T helper cells displayed profound defects in the expression of NFAT-regulated cytokine genes, including IL- ...[more]