Ontology highlight
ABSTRACT:
SUBMITTER: Isom DG
PROVIDER: S-EPMC2841886 | biostudies-other | 2010 Mar
REPOSITORIES: biostudies-other
Isom Daniel G DG Vardy Eyal E Oas Terrence G TG Hellinga Homme W HW
Proceedings of the National Academy of Sciences of the United States of America 20100301 11
The Gibbs free energy difference between native and unfolded states ("stability") is one of the fundamental characteristics of a protein. By exploiting the thermodynamic linkage between ligand binding and stability, interactions of a protein with small molecules, nucleic acids, or other proteins can be detected and quantified. Determination of protein stability can therefore provide a universal monitor of biochemical function. Yet, the use of stability measurements as a functional probe is under ...[more]