Ontology highlight
ABSTRACT:
SUBMITTER: Schinazi RF
PROVIDER: S-EPMC284439 | biostudies-other | 1994 Feb
REPOSITORIES: biostudies-other
Schinazi R F RF Lloyd R M RM Ramanathan C S CS Taylor E W EW
Antimicrobial agents and chemotherapy 19940201 2
A statistically significant correlation exists between the locations of drug resistance mutations (DRMs) observed for various reverse transcriptase inhibitors and features of the secondary structure predicted for the RNA coding for human immunodeficiency virus type 1 reverse transcriptase. The known DRMs map onto "unstable" bases, which are predominantly nonhelical regions (i.e., loops, bulges, and bends) of the predicted RNA secondary structure, whereas codons for the key conserved residues of ...[more]