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Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum.

ABSTRACT: The marine-derived fungus Cadophora malorum was isolated from the green alga Enteromorpha sp. Growth on a biomalt medium supplemented with sea salt yielded an extract, from which we have isolated sclerosporin and four new hydroxylated sclerosporin derivatives, namely, 15-hydroxysclerosporin (2), 12-hydroxysclerosporin (3), 11-hydroxysclerosporin (4), and 8-hydroxysclerosporin (5). The compounds were evaluated in various biological activity assays. Compound 5 showed a weak fat-accumulation inhibitory activity against 3T3-L1 murine adipocytes.

SUBMITTER: Almeida C

PROVIDER: S-EPMC2846207 | biostudies-other | 2010 Mar

REPOSITORIES: biostudies-other

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Hydroxylated sclerosporin derivatives from the marine-derived fungus Cadophora malorum.

Almeida Celso C Eguereva Ekaterina E Kehraus Stefan S Siering Carsten C König Gabriele M GM

Journal of natural products 20100301 3

The marine-derived fungus Cadophora malorum was isolated from the green alga Enteromorpha sp. Growth on a biomalt medium supplemented with sea salt yielded an extract, from which we have isolated sclerosporin and four new hydroxylated sclerosporin derivatives, namely, 15-hydroxysclerosporin (2), 12-hydroxysclerosporin (3), 11-hydroxysclerosporin (4), and 8-hydroxysclerosporin (5). The compounds were evaluated in various biological activity assays. Compound 5 showed a weak fat-accumulation inhibi ...[more]

PMID: 20052971

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