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Prevention, screening and treatment of colorectal cancer: a global and regional generalized cost effectiveness analysis.


ABSTRACT: BACKGROUND: Regional generalized cost-effectiveness estimates of prevention, screening and treatment interventions for colorectal cancer are presented. METHODS: Standardised WHO-CHOICE methodology was used. A colorectal cancer model was employed to provide estimates of screening and treatment effectiveness. Intervention effectiveness was determined via a population state-transition model (PopMod) that simulates the evolution of a sub-regional population accounting for births, deaths and disease epidemiology. Economic costs of procedures and treatment were estimated, including programme overhead and training costs. RESULTS: In regions characterised by high income, low mortality and high existing treatment coverage, the addition of screening to the current high treatment levels is very cost-effective, although no particular intervention stands out in cost-effectiveness terms relative to the others.In regions characterised by low income, low mortality with existing treatment coverage around 50%, expanding treatment with or without screening is cost-effective or very cost-effective. Abandoning treatment in favour of screening (no treatment scenario) would not be cost effective.In regions characterised by low income, high mortality and low treatment levels, the most cost-effective intervention is expanding treatment. CONCLUSIONS: From a cost-effectiveness standpoint, screening programmes should be expanded in developed regions and treatment programmes should be established for colorectal cancer in regions with low treatment coverage.

SUBMITTER: Ginsberg GM 

PROVIDER: S-EPMC2850877 | biostudies-other | 2010

REPOSITORIES: biostudies-other

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Prevention, screening and treatment of colorectal cancer: a global and regional generalized cost effectiveness analysis.

Ginsberg Gary M GM   Lim Stephen S SS   Lauer Jeremy A JA   Johns Benjamin P BP   Sepulveda Cecilia R CR  

Cost effectiveness and resource allocation : C/E 20100317


<h4>Background</h4>Regional generalized cost-effectiveness estimates of prevention, screening and treatment interventions for colorectal cancer are presented.<h4>Methods</h4>Standardised WHO-CHOICE methodology was used. A colorectal cancer model was employed to provide estimates of screening and treatment effectiveness. Intervention effectiveness was determined via a population state-transition model (PopMod) that simulates the evolution of a sub-regional population accounting for births, deaths  ...[more]

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