Ontology highlight
ABSTRACT:
SUBMITTER: Labriola JM
PROVIDER: S-EPMC2856239 | biostudies-other | 2010 Apr
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20100204 14
Nicotinic acetylcholine receptors mediate fast synaptic transmission by fluxing ions across the membrane in response to neurotransmitter binding. We show here that during affinity purification of the nicotinic acetylcholine receptor from Torpedo, phosphatidic acid, but not other anionic or zwitterionic phospholipids, is hydrolyzed to diacylglycerol. The phospholipase C activity elutes with the acetylcholine receptor and is inhibited by a lipid phosphate phosphohydrolase inhibitor, sodium vanadat ...[more]