Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC2859499 | biostudies-other | 2010 Apr
REPOSITORIES: biostudies-other
Li Meng M Wang He H Huang Tao T Wang Jiyong J Ding Yu Y Li Zhenfei Z Zhang Jinkuo J Li Lin L
The Journal of biological chemistry 20100301 18
The TAK1-NLK cascade is a mitogen-activated protein kinase-related pathway that plays an inhibitory role in canonical Wnt/beta-catenin signaling through regulating the LEF1/TCF family transcriptional factors. TAB2 (TAK1-binding protein 2) is a putative TAK1 interacting protein that is involved in the regulation of TAK1. Here, we found that TAB2 could directly interact with NLK and function as a scaffold protein to facilitate the interaction between TAK1 and NLK. Knocking down TAB2 using small in ...[more]