Wnt/beta-catenin signaling: components, mechanisms, and diseases.
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ABSTRACT:
SUBMITTER: MacDonald BT
PROVIDER: S-EPMC2861485 | biostudies-other | 2009 Jul
REPOSITORIES: biostudies-other
Publications
Wnt/beta-catenin signaling: components, mechanisms, and diseases.
MacDonald Bryan T BT Tamai Keiko K He Xi X
Developmental cell 20090701 1
Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent progress in this so-called canonical Wnt signaling pathway. We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate beta-catenin stability, from Wnt receptors to the cytoplasmic beta-catenin destruction complex, and nuclear machinery ...[more]
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