Ontology highlight
ABSTRACT:
SUBMITTER: Jin B
PROVIDER: S-EPMC2863211 | biostudies-other | 2010 May
REPOSITORIES: biostudies-other
Jin Baofeng B Shen Huangxuan H Lin Shuibin S Li Jian-Liang JL Chen Zirong Z Griffin James D JD Wu Lizi L
The Journal of biological chemistry 20100315 19
Nuclear factor-kappaB (NF-kappaB)-based signaling regulates diverse biological processes, and its deregulation is associated with various disorders including autoimmune diseases and cancer. Identification of novel factors that modulate NF-kappaB function is therefore of significant importance. The Mastermind-like 1 (MAML1) transcriptional co-activator regulates transcriptional activity in the Notch pathway and is emerging as a co-activator of other pathways. In this study, we found that MAML1 re ...[more]