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High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239.

ABSTRACT: Human and simian immunodeficiency viruses (HIV and SIV) downregulate major histocompatibility complex class I (MHC-I) molecules from the surface of infected cells. Although this activity is conserved across viral isolates, its importance in AIDS pathogenesis is not clear. We therefore developed an assay to detect the level of MHC-I expression of SIV-infected cells directly ex vivo. Here we show that the extent of MHC-I downregulation is greatest in SIVmac239-infected macaques that never effectively control virus replication. Our results suggest that a high level of MHC-I downregulation is a hallmark of fast disease progression in SIV infection.

SUBMITTER: Friedrich TC 

PROVIDER: S-EPMC2863841 | biostudies-other | 2010 May

REPOSITORIES: biostudies-other

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High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239.

Friedrich Thomas C TC   Piaskowski Shari M SM   León Enrique J EJ   Furlott Jessica R JR   Maness Nicholas J NJ   Weisgrau Kimberly L KL   Mac Nair Caitlin E CE   Weiler Andrea M AM   Loffredo John T JT   Reynolds Matthew R MR   Williams K Y KY   Klimentidis Yann C YC   Wilson Nancy A NA   Allison David B DB   Rakasz Eva G EG  

Journal of virology 20100310 10

Human and simian immunodeficiency viruses (HIV and SIV) downregulate major histocompatibility complex class I (MHC-I) molecules from the surface of infected cells. Although this activity is conserved across viral isolates, its importance in AIDS pathogenesis is not clear. We therefore developed an assay to detect the level of MHC-I expression of SIV-infected cells directly ex vivo. Here we show that the extent of MHC-I downregulation is greatest in SIVmac239-infected macaques that never effectiv  ...[more]