Ontology highlight
ABSTRACT:
SUBMITTER: Browner MF
PROVIDER: S-EPMC286712 | biostudies-other | 1989 Mar
REPOSITORIES: biostudies-other
Browner M F MF Nakano K K Bang A G AG Fletterick R J RJ
Proceedings of the National Academy of Sciences of the United States of America 19890301 5
The cDNA for human muscle glycogen synthase encodes a protein of 737 amino acids. The primary structure of glycogen synthase is not related either to bacterial glycogen synthase or to any glycogen phosphorylase. All nine of the serines that are phosphorylated in the rabbit muscle enzyme in vivo are conserved in the human muscle sequence. The amino- and carboxyl-terminal fragments, which contain all the phosphorylation sites, are very negatively charged. Overall the unphosphorylated protein has a ...[more]