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A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.

ABSTRACT: We have isolated genomic and cDNA clones for a Drosophila gene resembling the human beta-amyloid precursor protein (APP). This gene produces a nervous system-enriched 6.5-kilobase transcript. Sequencing of cDNAs derived from the 6.5-kilobase transcript predicts an 886-amino acid polypeptide. This polypeptide contains a putative transmembrane domain and exhibits strong sequence similarity to cytoplasmic and extracellular regions of the human beta-amyloid precursor protein. There is a high probability that this Drosophila gene corresponds to the essential Drosophila locus vnd, a gene required for embryonic nervous system development.

SUBMITTER: Rosen DR

PROVIDER: S-EPMC286936 | biostudies-other | 1989 Apr

REPOSITORIES: biostudies-other

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A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.

Rosen D R DR Martin-Morris L L Luo L Q LQ White K K

Proceedings of the National Academy of Sciences of the United States of America 19890401 7

We have isolated genomic and cDNA clones for a Drosophila gene resembling the human beta-amyloid precursor protein (APP). This gene produces a nervous system-enriched 6.5-kilobase transcript. Sequencing of cDNAs derived from the 6.5-kilobase transcript predicts an 886-amino acid polypeptide. This polypeptide contains a putative transmembrane domain and exhibits strong sequence similarity to cytoplasmic and extracellular regions of the human beta-amyloid precursor protein. There is a high probabi ...[more]

PMID: 2494667

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