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Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: case report.

ABSTRACT: BACKGROUND: The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial. CASE PRESENTATION: We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like episodes disappeared. Only after cyclosporine withdrawal the transcranial Doppler ultrasound abnormalities fully resolved. CONCLUSIONS: This case demonstrates a significant role of vasospasm in the pathway of cyclosporine-induced neurotoxicity. Transcranial Doppler ultrasound is an effective tool for the diagnosis and follow-up of cyclosporine-induced vasospasm.

SUBMITTER: Braakman HM

PROVIDER: S-EPMC2874792 | biostudies-other | 2010

REPOSITORIES: biostudies-other

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Vasospasm is a significant factor in cyclosporine-induced neurotoxicity: case report.

Braakman Hilde M H HM Lodder Jan J Postma Alida A AA Span Lambert F R LF Mess Werner H WH

BMC neurology 20100511

<h4>Background</h4>The aetiology of central nervous system lesions observed in cerebral cyclosporine neurotoxicity remains controversial.<h4>Case presentation</h4>We report a 48-year-old woman with a non-severe aplastic anaemia who presented with stroke-like episodes while on cyclosporine treatment.Transcranial Doppler ultrasound revealed severely elevated flow velocities in several cerebral vessels, consistent with vasospasm. Immediately after reducing the cyclosporine dose, the stroke-like epi ...[more]

PMID: 20459819

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