Tourette syndrome is associated with recurrent exonic copy number variants.
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ABSTRACT:
SUBMITTER: Sundaram SK
PROVIDER: S-EPMC2876824 | biostudies-other | 2010 May
REPOSITORIES: biostudies-other
Publications
Tourette syndrome is associated with recurrent exonic copy number variants.
Sundaram Senthil K SK Huq Ahm M AM Wilson Benjamin J BJ Chugani Harry T HT
Neurology 20100428 20
<h4>Background</h4>Multiple rare copy number variants (CNVs) including genomic deletions and duplications play a prominent role in neurodevelopmental disorders such as mental retardation, autism, and schizophrenia, but have not been systematically studied in Tourette syndrome (TS).<h4>Methods</h4>We performed a genome-wide screening of single nucleotide polymorphism (SNP) genotyping microarray data to identify recurrent or de novo rare exonic CNVs in a case-control association study of patients ...[more]
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