Decision Making by p53: Life versus Death.
Ontology highlight
ABSTRACT:
SUBMITTER: Jiang L
PROVIDER: S-EPMC2877278 | biostudies-other | 2010 Jan
REPOSITORIES: biostudies-other
Publications
Decision Making by p53: Life versus Death.
Jiang Lingyan L Sheikh M Saeed MS Huang Ying Y
Molecular and cellular pharmacology 20100101 2
Cellular response to DNA damage is multifacted in nature and involves a complex signaling network in which p53 functions as a "molecular node" for converging signals. p53 has been implicated in a variety of cellular processes primarily functioning as a transcription factor and also in a transcription-independent manner. It is rapidly activated following DNA damage with phosphorylation as one of the initial signals. Cellular context as well as the type and severity of DNA damage determine p53 act ...[more]
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