Ontology highlight
ABSTRACT:
SUBMITTER: Zucca S
PROVIDER: S-EPMC2878312 | biostudies-other | 2010 May
REPOSITORIES: biostudies-other
Zucca Stefano S Valenzuela C Fernando CF
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100501 19
Fetal alcohol spectrum disorder (FASD) is associated with learning and memory alterations that could be, in part, a consequence of hippocampal damage. The CA3 hippocampal subfield is one of the regions affected by ethanol (EtOH), including exposure during the third trimester-equivalent (i.e., neonatal period in rats). However, the mechanism of action of EtOH is poorly understood. In CA3 pyramidal neurons from neonatal rats, dendritic BDNF release causes long-term potentiation of the frequency of ...[more]