Unknown

Dataset Information

0

Low concentrations of alcohol inhibit BDNF-dependent GABAergic plasticity via L-type Ca2+ channel inhibition in developing CA3 hippocampal pyramidal neurons.


ABSTRACT: Fetal alcohol spectrum disorder (FASD) is associated with learning and memory alterations that could be, in part, a consequence of hippocampal damage. The CA3 hippocampal subfield is one of the regions affected by ethanol (EtOH), including exposure during the third trimester-equivalent (i.e., neonatal period in rats). However, the mechanism of action of EtOH is poorly understood. In CA3 pyramidal neurons from neonatal rats, dendritic BDNF release causes long-term potentiation of the frequency of GABAA receptor-mediated spontaneous postsynaptic currents (LTP-GABAA) and this mechanism is thought to play a role in GABAergic synapse maturation. Here, we show that short- and long-term exposure of neonatal male rats to low EtOH concentrations abolishes LTP-GABAA by inhibiting L-type voltage-gated Ca2+ channels. These findings support the recommendation that even light drinking should be avoided during pregnancy.

SUBMITTER: Zucca S 

PROVIDER: S-EPMC2878312 | biostudies-other | 2010 May

REPOSITORIES: biostudies-other

altmetric image

Publications

Low concentrations of alcohol inhibit BDNF-dependent GABAergic plasticity via L-type Ca2+ channel inhibition in developing CA3 hippocampal pyramidal neurons.

Zucca Stefano S   Valenzuela C Fernando CF  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100501 19


Fetal alcohol spectrum disorder (FASD) is associated with learning and memory alterations that could be, in part, a consequence of hippocampal damage. The CA3 hippocampal subfield is one of the regions affected by ethanol (EtOH), including exposure during the third trimester-equivalent (i.e., neonatal period in rats). However, the mechanism of action of EtOH is poorly understood. In CA3 pyramidal neurons from neonatal rats, dendritic BDNF release causes long-term potentiation of the frequency of  ...[more]

Similar Datasets

| S-EPMC3878388 | biostudies-literature
| S-EPMC5975193 | biostudies-literature
| S-EPMC5599651 | biostudies-literature
| S-EPMC2323611 | biostudies-literature
| S-EPMC3617474 | biostudies-literature
| S-EPMC5634406 | biostudies-literature
| S-EPMC5468507 | biostudies-literature
| S-EPMC5746169 | biostudies-literature
| S-EPMC2660276 | biostudies-literature
| S-EPMC3545206 | biostudies-literature