Ontology highlight
ABSTRACT:
SUBMITTER: Spieles-Engemann AL
PROVIDER: S-EPMC2879040 | biostudies-other | 2010 Jul
REPOSITORIES: biostudies-other
Spieles-Engemann A L AL Behbehani M M MM Collier T J TJ Wohlgenant S L SL Steece-Collier K K Paumier K K Daley B F BF Gombash S S Madhavan L L Mandybur G T GT Lipton J W JW Terpstra B T BT Sortwell C E CE
Neurobiology of disease 20100320 1
Deep brain stimulation of the subthalamic nucleus (STN-DBS) is efficacious in treating the motor symptoms of Parkinson's disease (PD). However, the impact of STN-DBS on the progression of PD is unknown. Previous preclinical studies have demonstrated that STN-DBS can attenuate the degeneration of a relatively intact nigrostriatal system from dopamine (DA)-depleting neurotoxins. The present study examined whether STN-DBS can provide neuroprotection in the face of prior significant nigral DA neuron ...[more]