Ontology highlight
ABSTRACT:
SUBMITTER: Sideras K
PROVIDER: S-EPMC2881853 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
Sideras Kostandinos K Ingle James N JN Ames Matthew M MM Loprinzi Charles L CL Mrazek David P DP Black John L JL Weinshilboum Richard M RM Hawse John R JR Spelsberg Thomas C TC Goetz Matthew P MP
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100503 16
Evidence has emerged that the clinical benefit of tamoxifen is related to the functional status of the hepatic metabolizing enzyme cytochrome P450 2D6 (CYP2D6). CYP2D6 is the key enzyme responsible for the generation of the potent tamoxifen metabolite, endoxifen. Multiple studies have examined the relationship of CYP2D6 status to breast cancer outcomes in tamoxifen-treated women; the majority of studies demonstrated that women with impaired CYP2D6 metabolism have lower endoxifen concentrations a ...[more]