Wrapped-around models for the lac operon complex.
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ABSTRACT:
SUBMITTER: La Penna G
PROVIDER: S-EPMC2884243 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
Publications
Wrapped-around models for the lac operon complex.
La Penna Giovanni G Perico Angelo A
Biophysical journal 20100601 12
The protein-DNA complex, involved in the lac operon of enteric bacteria, is paradigmatic in understanding the extent of DNA bending and plasticity due to interactions with protein assemblies acting as DNA regulators. For the lac operon, two classes of structures have been proposed: 1), with the protein tetramer lying away from the DNA loop (wrapped-away model); and 2), with the protein tetramer lying inside the DNA loop (wrapped-around model). A recently developed electrostatic analytical model ...[more]
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