Ontology highlight
ABSTRACT:
SUBMITTER: Jha S
PROVIDER: S-EPMC2886028 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
Jha Sudhakar S Vande Pol Scott S Banerjee Nilam Sanjib NS Dutta Arun Brendan AB Chow Louise T LT Dutta Anindya A
Molecular cell 20100601 5
The TIP60 tumor suppressor is a histone acetyltransferase involved in transcriptional regulation, checkpoint activation, and p53-directed proapoptotic pathways. We report that human papillomavirus (HPV) E6 destabilizes TIP60 both in vivo and in vitro. TIP60 binds to the HPV major early promoter and acetylates histone H4 to recruit Brd4, a cellular repressor of HPV E6 expression. Both low- and high-risk HPV E6 destabilize TIP60, thereby derepressing their own promoter. Destabilization of TIP60 by ...[more]