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Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact.


ABSTRACT: We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires approximately 10 s to complete one 3-D scan of approximately 2.5 x 2.5 mm(2). The system is sensitive to blood flow with a velocity ranging from approximately 4 microms to approximately 23 mms. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.

SUBMITTER: Jia Y 

PROVIDER: S-EPMC2887910 | biostudies-other | 2010 May-Jun

REPOSITORIES: biostudies-other

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