Ontology highlight
ABSTRACT:
SUBMITTER: Hanna J
PROVIDER: S-EPMC2889088 | biostudies-other | 2010 May
REPOSITORIES: biostudies-other
Hanna Jacob J Cheng Albert W AW Saha Krishanu K Kim Jongpil J Lengner Christopher J CJ Soldner Frank F Cassady John P JP Muffat Julien J Carey Bryce W BW Jaenisch Rudolf R
Proceedings of the National Academy of Sciences of the United States of America 20100504 20
Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos but have very different biological properties, and molecular analyses suggest that the pluripotent state of human ESCs isolated so far corresponds to that of mouse-derived epiblast stem cells (EpiSCs). Here we rewire the identity of conventional human ESCs into a more immature state that extensively shares defining features with pluripotent mouse ESCs. This was achieved by ectopic induction of Oct4, Klf4, and K ...[more]