Ontology highlight
ABSTRACT:
SUBMITTER: Vaira V
PROVIDER: S-EPMC2889536 | biostudies-other | 2010 May
REPOSITORIES: biostudies-other
Vaira Valentina V Fedele Giuseppe G Pyne Saumyadipta S Fasoli Ester E Zadra Giorgia G Bailey Dyane D Snyder Eric E Faversani Alice A Coggi Guido G Flavin Richard R Bosari Silvano S Loda Massimo M
Proceedings of the National Academy of Sciences of the United States of America 20100419 18
Predicting drug response in cancer patients remains a major challenge in the clinic. We have perfected an ex vivo, reproducible, rapid and personalized culture method to investigate antitumoral pharmacological properties that preserves the original cancer microenvironment. Response to signal transduction inhibitors in cancer is determined not only by properties of the drug target but also by mutations in other signaling molecules and the tumor microenvironment. As a proof of concept, we, therefo ...[more]