Ontology highlight
ABSTRACT:
SUBMITTER: Bernard D
PROVIDER: S-EPMC2889742 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
Bernard Dannie D Ventresca Michael S MS Marshall Laura A LA Evelegh Carole C Wan Yonghong Y Bramson Jonathan L JL
Molecular therapy : the journal of the American Society of Gene Therapy 20100223 6
CD4(+) T cells contribute to the antitumor T-cell response as both effectors that promote tumor rejection and helpers that facilitate the activation of other antitumor effector cells, such as CD8(+) T cells. Maximal engagement of both effector and helper CD4(+) T-cell responses is a desirable attribute of cancer vaccines. We have employed the B16F10 murine melanoma model and a series of recombinant adenovirus (Ad) vaccines expressing mutant forms of the tumor antigen, dopachrome tautomerase, to ...[more]