Ontology highlight
ABSTRACT:
SUBMITTER: Freir DB
PROVIDER: S-EPMC2891223 | biostudies-other | 2011 Dec
REPOSITORIES: biostudies-other
Neurobiology of aging 20100125 12
Extensive research has implicated the amyloid-β protein (Aβ) in the aetiology of Alzheimer's disease (AD). This protein has been shown to produce memory deficits when injected into rodent brain and in mouse models of AD Aβ production is associated with impaired learning and/or recall. Here we examined the effects of cell-derived SDS-stable 7PA2-derived soluble Aβ oligomers on consolidation of avoidance learning. At 0, 3, 6, 9 or 12h after training, animals received an intracerebroventricular inj ...[more]