Epstein-Barr virus DNA recombines via latent origin of replication with the human genome in the lymphoblastoid cell line RGN1.
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ABSTRACT:
SUBMITTER: Gualandi G
PROVIDER: S-EPMC289137 | biostudies-other | 1992 Sep
REPOSITORIES: biostudies-other
Publications
Epstein-Barr virus DNA recombines via latent origin of replication with the human genome in the lymphoblastoid cell line RGN1.
Gualandi G G Santolini E E Calef E E
Journal of virology 19920901 9
We show here that in a lymphoblastoid cell line Epstein-Barr virus DNA recombines with the human genome. The genetic exchange involves the oriP region of the virus. A junction between viral and human DNA from this line has been cloned and sequenced. The results indicate that the integration of Epstein-Barr virus DNA involves a region of the human genome which contains internal short repetition. An 800-bp probe has been isolated from the human part of the junction. This probe has been used to sho ...[more]
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