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Gene--environment-wide association studies: emerging approaches.

ABSTRACT: Despite the yield of recent genome-wide association (GWA) studies, the identified variants explain only a small proportion of the heritability of most complex diseases. This unexplained heritability could be partly due to gene--environment (G×E) interactions or more complex pathways involving multiple genes and exposures. This Review provides a tutorial on the available epidemiological designs and statistical analysis approaches for studying specific G×E interactions and choosing the most appropriate methods. I discuss the approaches that are being developed for studying entire pathways and available techniques for mining interactions in GWA data. I also explore methods for marrying hypothesis-driven pathway-based approaches with 'agnostic' GWA studies.

SUBMITTER: Thomas D

PROVIDER: S-EPMC2891422 | biostudies-other | 2010 Apr

REPOSITORIES: biostudies-other

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Gene--environment-wide association studies: emerging approaches.

Thomas Duncan D

Nature reviews. Genetics 20100401 4

Despite the yield of recent genome-wide association (GWA) studies, the identified variants explain only a small proportion of the heritability of most complex diseases. This unexplained heritability could be partly due to gene--environment (G×E) interactions or more complex pathways involving multiple genes and exposures. This Review provides a tutorial on the available epidemiological designs and statistical analysis approaches for studying specific G×E interactions and choosing the most approp ...[more]

PMID: 20212493

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