Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model.
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ABSTRACT:
SUBMITTER: Duan F
PROVIDER: S-EPMC2895089 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
Publications
Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model.
Proceedings of the National Academy of Sciences of the United States of America 20100607 25
To investigate the possibility of using commensal bacteria as signal mediators for inhibiting the disease cholera, we stably transformed Escherichia coli Nissle 1917 (Nissle) to express the autoinducer molecule cholera autoinducer 1 (CAI-1) (shown previously to prevent virulence when present with another signaling molecule, autoinducer 2, at high concentrations) and determined the effect on Vibrio cholerae virulence gene expression and colonization in an infant mouse model. We found that pretrea ...[more]
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