Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz N
PROVIDER: S-EPMC2901483 | biostudies-other | 2010 Jul
REPOSITORIES: biostudies-other
Ruiz Natividad N Chng Shu-Sin SS Hiniker Annie A Kahne Daniel D Silhavy Thomas J TJ
Proceedings of the National Academy of Sciences of the United States of America 20100621 27
The Gram-negative bacterial envelope is bounded by two membranes. Disulfide bond formation and isomerization in this oxidizing environment are catalyzed by DsbA and DsbC, respectively. It remains unknown when and how the Dsb proteins participate in the biogenesis of outer membrane proteins, which are transported across the cell envelope after their synthesis. The Escherichia coli protein LptD is an integral outer membrane protein that forms an essential complex with the lipoprotein LptE. We show ...[more]