Ontology highlight
ABSTRACT:
SUBMITTER: Means JC
PROVIDER: S-EPMC2906863 | biostudies-other | 2010 May
REPOSITORIES: biostudies-other
Means John C JC Passarelli A Lorena AL
Proceedings of the National Academy of Sciences of the United States of America 20100510 21
Most arthropod-borne and invertebrate viruses are orally ingested and commence infection in cells of the invertebrate intestine. Infection of secondary sites and eventual transmission to other hosts is hindered by basal lamina, a tightly interwoven and virus-impenetrable noncellular layer, lining the intestine and other organ cell layers. The mechanisms for viral escape across basal laminae are unknown. We describe an elegant mechanism mediated by a baculovirus-encoded fibroblast growth factor ( ...[more]