Ontology highlight
ABSTRACT:
SUBMITTER: Deghorain M
PROVIDER: S-EPMC2911304 | biostudies-other | 2010 Jul
REPOSITORIES: biostudies-other
Deghorain Marie M Fontaine Laetitia L David Blandine B Mainardi Jean-Luc JL Courtin Pascal P Daniel Richard R Errington Jeff J Sorokin Alexei A Bolotin Alexander A Chapot-Chartier Marie-Pierre MP Hallet Bernard B Hols Pascal P
The Journal of biological chemistry 20100604 31
Cell wall peptidoglycan assembly is a tightly regulated process requiring the combined action of multienzyme complexes. In this study we provide direct evidence showing that substrate transformations occurring at the different stages of this process play a crucial role in the spatial and temporal coordination of the cell wall synthesis machinery. Peptidoglycan substrate alteration was investigated in the Gram-positive bacterium Lactococcus lactis by substituting the peptidoglycan precursor biosy ...[more]