Ontology highlight
ABSTRACT:
SUBMITTER: Choi H
PROVIDER: S-EPMC2913403 | biostudies-other | 2010 Jun
REPOSITORIES: biostudies-other
Choi Hyungwon H Kim Sinae S Gingras Anne-Claude AC Nesvizhskii Alexey I AI
Molecular systems biology 20100601
Affinity purification followed by mass spectrometry (AP-MS) has become a common approach for identifying protein-protein interactions (PPIs) and complexes. However, data analysis and visualization often rely on generic approaches that do not take advantage of the quantitative nature of AP-MS. We present a novel computational method, nested clustering, for biclustering of label-free quantitative AP-MS data. Our approach forms bait clusters based on the similarity of quantitative interaction profi ...[more]